Semaglutide and Tirzepatide belong to a class known as incretin therapies. They work with your body's own appetite and metabolic signaling rather than against it, which is part of why they have changed the clinical picture for so many people.
These medications act on receptors in regions of the brain that regulate hunger and fullness. They also slow how quickly the stomach empties after a meal. The combined effect is that you feel satisfied sooner, stay satisfied longer, and experience fewer of the cravings that make sustained change so difficult through diet alone.
A GLP-1 receptor agonist. It mimics a naturally occurring gut hormone that signals fullness to the brain and moderates appetite, helping reduce overall food intake.
A dual receptor agonist acting on both GLP-1 and GIP pathways. By engaging two complementary signaling systems, it broadens the metabolic effect on appetite and energy balance.
This is a clinical decision, not a menu choice. The physician reviewing your case weighs your health history, your goals, your tolerance, and your response over time. What suits one person may not suit another, and your plan can be adjusted as your body responds.
Both medications are typically started at a low dose and increased gradually. This titration approach gives your body time to adapt and helps reduce the likelihood and intensity of side effects. Your provider sets the schedule that fits you.
Because these medications slow digestion, the most common side effects are gastrointestinal. For most people they are mild to moderate and tend to ease as the body adjusts, particularly when dosing is increased gradually under physician guidance.
Nausea, reduced appetite, mild digestive changes, or feeling full quickly. These are most noticeable early and often settle with time and careful titration.
Persistent or severe symptoms should always be discussed with your care team. Your provider can adjust your dose or approach rather than leaving you to push through.
Your plan is not set in stone. Ongoing physician access means side effects are something your care team helps you navigate, not something you face alone.
These medications are prepared by an FDA-registered 503B pharmacy and require a valid prescription from a licensed provider. They are not appropriate for everyone, which is exactly why a physician reviews your individual case before anything is prescribed.
These are powerful clinical tools, and the most responsible way to use them is with clear expectations. They are not a quick fix, and they work best as part of an approach that includes nutrition and movement. They typically require continued use to maintain their effect, and discontinuation can lead to changes that your physician will discuss with you.
KERNX believes you should understand your treatment as well as your provider does. The more you know about how these medications work and what they ask of you, the better positioned you are to use them successfully.
FOUNDING MEMBER WAITLIST
Founding rates start at $129 per month, available during the first 60 days. Join the list and we will reach out as we prepare to launch.
Thank you for joining. We will reach out with the next steps as we prepare to launch.